Delta-Valerolactone

 

Product Name:

Delta-Valerolactone

Molecular Formula:

C₅H₈O₂

CAS No.:

542-28-9

EINECS No.: 208-807-1            TSCA： Listed    

Molecular Weight: 100.12

Synonyms:  Tetrahydro-2H-2-pyranone

Chemical Structure:                 

Physical and chemical properties: Colorless to slightly yellow liquid, Melting point -13 - -12 °C (9 - 10 °F) - lit.; Boiling point 58 - 60 °C (136 - 140 °F) at 0.7 hPa (0.5 mmHg) - lit.

226 - 229 °C (439 - 444 °F) - lit.; Flash point 112 °C (234 °F) - closed cup; Density 1.079 g/cm3 at 25 °C (77 °F)

Specification:

Item	MIN.	MAX.
Purity, %	99.0
Moisture,%		0.15
Acid value ,KOH mg/g		0.3

Application: Delta-Valerolactone is an important intermediate for organic synthesis with wide application:

1. Delta-Valerolactone is used together with cyclohexylamine to synthesize1-Cyclohexyl-5-(4-chlorobutyl)-1H-tetrazole ( an raw material of Cilostazol)

2. Used to synthesize 2,3-dihydrofuran ( raw material for Misoprostol and dinoprost)

3. Used to synthesize (+)Quebrachamine

4. Used to synthesize 2,4- bis-substituted pyran ( 2,3-d) pyrimidine ( as germicide and herbicide )

5. Used together with Ethyl trifluoroacetate to synthesize Trifluoroacety- Delta-Valerolactone

6. Easy for ring-opening polymerization, so widely used in pharmaceutical and liquid crystal.

7. Used together with other lactones ( such as epsilon-caprolactone ) to synthesize polylactides. Due to the polylactides’ bio-degradability, good flexibility, transparency and other properties, the polylactides are used in wound management.

8. Used to synthesize environmental protection plastic, which can be used in surgical operation as absorbable suture, in sunscreen, cosmetic, etc.

9. Used to synthesize (+)Phoiboxazole                                                                                                                                    Handling and Storage:

Avoid inhalation of vapour or mist. Normal measures for preventive fire protection.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.